As reported by PA Media, Charles expressed his “deepest concern” and emphasised that “the law must take its course”.
The monarch said: “I have learned with the deepest concern the news about Andrew Mountbatten-Windsor and suspicion of misconduct in public office.
“What now follows is the full, fair and proper process by which this issue is investigated in the appropriate manner and by the appropriate authorities.
“In this, as I have said before, they have our full and wholehearted support and co-operation.”
He continued: “Let me state clearly: the law must take its course. As this process continues, it would not be right for me to comment further on this matter.
“Meanwhile, my family and I will continue in our duty and service to you all. Charles R.”
Charles had previously commented on the allegations involving his brother. A Buckingham Palace spokesperson said at the time: “The King has made clear, in words and through unprecedented actions, his profound concern at allegations which continue to come to light in respect of Mr Mountbatten-Windsor’s conduct.”
The statement added: “While the specific claims in question are for Mr Mountbatten-Windsor to address, if we are approached by Thames Valley Police, we stand ready to support them as you would expect.
“As was previously stated, Their Majesties’ thoughts and sympathies have been, and remain with, the victims of any and all forms of abuse.”
The Prince and Princess of Wales also publicly addressed the Epstein scandal earlier this month, with Kensington Palace stating: “I can confirm that the Prince and Princess of Wales have been deeply concerned by the continued revelations.
“Their thoughts remain focused on the victims.”
Virginia Giuffre’s family responds
The family of Virginia Giuffre have also spoken out following Andrew’s arrest.
Andrew has faced allegations — which he strongly denies — that he sexually assaulted Giuffre when she was a teenager after she was trafficked by Epstein. In 2022, he paid millions to settle a civil sexual assault claim brought by Giuffre, a woman he maintains he never met. Giuffre died by suicide in April 2025.
Her siblings told CBS News: “At last, today, our broken hearts have been lifted at the news that no one is above the law, not even royalty.