If you’re among the millions of people controlling high blood pressure (hypertension), your daily routine likely includes some mixture of medication, diet, and lifestyle changes. But did you know that certain common pills—even over-the-counter ones—could be silently raising your blood pressure and increasing your risk of stroke or heart attack?

Let’s be clear: This isn’t about scaring you away from necessary medication. It’s about empowering you with information so you can have informed conversations with your doctor and pharmacist.

Why This Matters

High blood pressure affects nearly half of all adults in the United States—about 116 million people. For those managing this condition, every medication counts. But many people don’t realize that common over-the-counter drugs, supplements, and even prescription medications can:

  • Raise blood pressure
  • Interfere with blood pressure medications
  • Increase heart rate

  • Cause fluid retention

  • Worsen hypertension symptoms

Over-the-Counter Medications to Watch

1. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Common names: Ibuprofen (Advil, Motrin), Naproxen (Aleve), Diclofenac, Celecoxib

What they do: Reduce pain and inflammation

The risk: NSAIDs can cause the body to retain sodium and fluid, which increases blood pressure. They can also reduce the effectiveness of many common blood pressure medications, including:

  • Diuretics
  • ACE inhibitors
  • Beta-blockers

  • Angiotensin II receptor blockers

  • Safer alternatives:
  • Acetaminophen (Tylenol) – but use with caution if you have liver issues